儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號: PT0950R
特異性: Endogenous
基因名稱: CUL4A/CUL4B
蛋白名稱: Cullin-4A (CUL-4A)/Cullin-4B
別名: CUL4B;KIAA0695;Cullin-4B;CUL-4B
Organism-1: Human
基因ID-1: 8451;8450
SwissProt-1: Q13619;Q13620
Organism-2: Mouse
SwissProt-2: Q3TCH7,A2A432
背景: CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009],CUL4B is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號: PT0950R
特異性: Endogenous
基因名稱: CUL4A/CUL4B
蛋白名稱: Cullin-4A (CUL-4A)/Cullin-4B
別名: CUL4B;KIAA0695;Cullin-4B;CUL-4B
Organism-1: Human
基因ID-1: 8451;8450
SwissProt-1: Q13619;Q13620
Organism-2: Mouse
SwissProt-2: Q3TCH7,A2A432
背景: CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009],CUL4B is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
細(xì)胞定位: Nucleus .Cytoplasm.
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