儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號: PT0887R
特異性: Endogenous
基因名稱: NR1H3
蛋白名稱: Oxysterols receptor LXR-alpha
別名: NR1H3;LXRA;Oxysterols receptor LXR-alpha;Liver X receptor alpha;Nuclear receptor subfamily 1 group H member 3
Organism-1: Human
基因ID-1: 10062
SwissProt-1: Q13133
Organism-2: Mouse
基因ID-2: 22259
SwissProt-2: Q9Z0Y9
Organism-3: Rat
SwissProt-3: Q62685
背景: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號: PT0887R
特異性: Endogenous
基因名稱: NR1H3
蛋白名稱: Oxysterols receptor LXR-alpha
別名: NR1H3;LXRA;Oxysterols receptor LXR-alpha;Liver X receptor alpha;Nuclear receptor subfamily 1 group H member 3
Organism-1: Human
基因ID-1: 10062
SwissProt-1: Q13133
Organism-2: Mouse
基因ID-2: 22259
SwissProt-2: Q9Z0Y9
Organism-3: Rat
SwissProt-3: Q62685
背景: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
細(xì)胞定位: Nucleus . Cytoplasm .
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