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MMP9 Rabbit mAb

商品貨號(hào)： PRM8626

適應(yīng) 性： 小鼠,大鼠,

￥7000元

規(guī)格：

500ul

在線咨詢

MSDS

說明書

商品描述

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： MMP-9
反應(yīng)性-Reactivity：小鼠,大鼠,
應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:200-1000;WB 1:500-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號(hào)： PT0731R
特異性： Endogenous
基因名稱： MMP9 CLG4B
蛋白名稱： MMP9 (Cleaved-Met94)
別名： Matrix metalloproteinase-9;MMP-9;92 kDa gelatinase;92 kDa type IV collagenase;Gelatinase B;GELB;[Cleaved into: 67 kDa matrix metalloproteinase-9;82 kDa matrix metalloproteinase-9]
Organism-1： Human
基因ID-1： 4318
SwissProt-1： P14780
Organism-2： Mouse
基因ID-2： 17395
SwissProt-2： P41245
Organism-3： Rat
基因ID-3： 81687
SwissProt-3： P50282
背景： catalytic activity:Cleavage of gelatin types I and V and collagen types IV and V.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,disease:Defects in MMP9 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5).,function:May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.,induction:Activated by 4-aminophenylmercuric acetate and phorbol ester.,miscellaneous:In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.,PTM:N- and O-glycosylated.,PTM:Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 3 fibronectin type-II domains.,similarity:Contains 4 hemopexin-like domains.,subunit:Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.,tissue specificity:Produced by normal alveolar macrophages and granulocytes.,
細(xì)胞定位： Membranous

MMP9 Rabbit mAb

Catalog No PRM8626

Product information

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： MMP-9
反應(yīng)性-Reactivity：小鼠,大鼠,
應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:200-1000;WB 1:500-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號(hào)： PT0731R
特異性： Endogenous
基因名稱： MMP9 CLG4B
蛋白名稱： MMP9 (Cleaved-Met94)
別名： Matrix metalloproteinase-9;MMP-9;92 kDa gelatinase;92 kDa type IV collagenase;Gelatinase B;GELB;[Cleaved into: 67 kDa matrix metalloproteinase-9;82 kDa matrix metalloproteinase-9]
Organism-1： Human
基因ID-1： 4318
SwissProt-1： P14780
Organism-2： Mouse
基因ID-2： 17395
SwissProt-2： P41245
Organism-3： Rat
基因ID-3： 81687
SwissProt-3： P50282
背景： catalytic activity:Cleavage of gelatin types I and V and collagen types IV and V.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,disease:Defects in MMP9 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5).,function:May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.,induction:Activated by 4-aminophenylmercuric acetate and phorbol ester.,miscellaneous:In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.,PTM:N- and O-glycosylated.,PTM:Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 3 fibronectin type-II domains.,similarity:Contains 4 hemopexin-like domains.,subunit:Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.,tissue specificity:Produced by normal alveolar macrophages and granulocytes.,
細(xì)胞定位： Membranous

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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