儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性: Monoclonal
克隆號: PT0456R
特異性: Endogenous
基因名稱: TP53BP1
蛋白名稱: Tumor suppressor p53-binding protein 1
別名: TP53BP1;Tumor suppressor p53-binding protein 1;53BP1;p53-binding protein 1;p53BP1
Organism-1: Human
基因ID-1: 7158
SwissProt-1: Q12888
Organism-2: Mouse
基因ID-2: 27223
SwissProt-2: P70399
背景: This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性: Monoclonal
克隆號: PT0456R
特異性: Endogenous
基因名稱: TP53BP1
蛋白名稱: Tumor suppressor p53-binding protein 1
別名: TP53BP1;Tumor suppressor p53-binding protein 1;53BP1;p53-binding protein 1;p53BP1
Organism-1: Human
基因ID-1: 7158
SwissProt-1: Q12888
Organism-2: Mouse
基因ID-2: 27223
SwissProt-2: P70399
背景: This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
細(xì)胞定位: Nucleus
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