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LATS1 Rabbit mAb

商品貨號： PRM8251

適應(yīng) 性： 人,小鼠,大鼠

￥800元

規(guī)格：

50ul

在線咨詢

MSDS

說明書

商品描述

發(fā)貨日期：現(xiàn)貨
靶點-Target： LATS1
反應(yīng)性-Reactivity：人,小鼠,大鼠
應(yīng)用-Applications： WB,IF,IP,ELISA
MW(Calculated)： 127kD
MW(Observed)： 140kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT0609R
特異性： Endogenous
基因名稱： LATS1 WARTS
蛋白名稱： Serine/threonine-protein kinase LATS1 (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
別名： Serine/threonine-protein kinase LATS1;Large tumor suppressor homolog 1;WARTS protein kinase;h-warts;
Organism-1： Human
基因ID-1： 9113
SwissProt-1： O95835
Organism-2： Mouse
基因ID-2： 16798
SwissProt-2： Q8BYR2
背景： The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen
細(xì)胞定位： Cytoplasm

LATS1 Rabbit mAb

Catalog No PRM8251

Product information

發(fā)貨日期：現(xiàn)貨
靶點-Target： LATS1
反應(yīng)性-Reactivity：人,小鼠,大鼠
應(yīng)用-Applications： WB,IF,IP,ELISA
MW(Calculated)： 127kD
MW(Observed)： 140kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT0609R
特異性： Endogenous
基因名稱： LATS1 WARTS
蛋白名稱： Serine/threonine-protein kinase LATS1 (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
別名： Serine/threonine-protein kinase LATS1;Large tumor suppressor homolog 1;WARTS protein kinase;h-warts;
Organism-1： Human
基因ID-1： 9113
SwissProt-1： O95835
Organism-2： Mouse
基因ID-2： 16798
SwissProt-2： Q8BYR2
背景： The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen
細(xì)胞定位： Cytoplasm

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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