儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT0726R
特異性： Endogenous
基因名稱： MECP2
蛋白名稱： Methyl-CpG-binding protein 2
別名： Methyl-CpG-binding protein 2;MeCp-2 protein;MeCp2;
Organism-1： Human
基因ID-1： 4204
SwissProt-1： P51608
Organism-2： Mouse
基因ID-2： 17257
SwissProt-2： Q9Z2D6
Organism-3： Rat
基因ID-3： 29386
SwissProt-3： Q00566
背景： DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT0726R
特異性： Endogenous
基因名稱： MECP2
蛋白名稱： Methyl-CpG-binding protein 2
別名： Methyl-CpG-binding protein 2;MeCp-2 protein;MeCp2;
Organism-1： Human
基因ID-1： 4204
SwissProt-1： P51608
Organism-2： Mouse
基因ID-2： 17257
SwissProt-2： Q9Z2D6
Organism-3： Rat
基因ID-3： 29386
SwissProt-3： Q00566
背景： DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor
細胞定位： Nucleus
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