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EKLF (Acetyl Lys274) rabbit pAb

商品貨號： PLN000151

適應(yīng) 性： 人,大鼠,小鼠,

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： KLF1 EKLF
蛋白名稱： EKLF (Acetyl Lys274)
Human_gene_id： 10661
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10661
Human_swiss_prot_no： Q13351
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q13351/entry
Mouse_gene_link： https://www.uniprot.org/uniprot/0
Mouse_swiss_prot_no： P46099
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P46099
特異性： This antibody detects endogenous levels of Human EKLF (Acetyl Lys274)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Krueppel-like factor 1 (Erythroid krueppel-like transcription factor;EKLF)
實測條帶： 40kD
功能： function:Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. When sumoylation, acts as a Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor, by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.,PTM:Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity.,PTM:Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity.,PTM:Sumoylated; sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subcellular location:Colocalizes with SUMO1 in nuclear speckles.,subunit:Interacts with CBP and EP300; the interactions enhance the transactivation activity. Interacts with PCAF; the interaction does not acetylate EKLF and inhibits its transactivation activity.,tissue specificity:Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3191
細(xì)胞定位： Nucleus . Colocalizes with SUMO1 in nuclear speckles. .
組織表達(dá)： Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.
科研貨號： PLN000151

EKLF (Acetyl Lys274) rabbit pAb

Catalog No PLN000151

Product information

基因名稱： KLF1 EKLF
蛋白名稱： EKLF (Acetyl Lys274)
Human_gene_id： 10661
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10661
Human_swiss_prot_no： Q13351
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q13351/entry
Mouse_gene_link： https://www.uniprot.org/uniprot/0
Mouse_swiss_prot_no： P46099
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P46099
特異性： This antibody detects endogenous levels of Human EKLF (Acetyl Lys274)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Krueppel-like factor 1 (Erythroid krueppel-like transcription factor;EKLF)
實測條帶： 40kD
功能： function:Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. When sumoylation, acts as a Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor, by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.,PTM:Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity.,PTM:Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity.,PTM:Sumoylated; sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subcellular location:Colocalizes with SUMO1 in nuclear speckles.,subunit:Interacts with CBP and EP300; the interactions enhance the transactivation activity. Interacts with PCAF; the interaction does not acetylate EKLF and inhibits its transactivation activity.,tissue specificity:Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3191
細(xì)胞定位： Nucleus . Colocalizes with SUMO1 in nuclear speckles. .
組織表達(dá)： Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.
科研貨號： PLN000151

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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