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E2F-4 (Acetyl Lys96) Polyclonal Antibody

商品貨號： PLN000025

適應性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： E2F4
蛋白名稱： Transcription factor E2F4
Human_gene_id： 1874
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1874
Human_swiss_prot_no： Q16254
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q16254/entry
Mouse_gene_id： 104394
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=104394
Mouse_swiss_prot_no： Q8R0K9
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8R0K9
特異性： Acetyl-E2F-4 (K96) Polyclonal Antibody detects endogenous levels of E2F-4 protein only when acetylated at K96.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： E2F4; Transcription factor E2F4; E2F-4
實測條帶： 43kD
信號通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;TGF-beta;
功能： developmental stage:Present in the growth-arrested state, its abundance does not change significantly as cells move into and through the cell cycle.,function:Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-4 binds with high affinity to RBL1 and RBL2. In some instances, can also bind RB protein.,polymorphism:The poly-Ser region of E2F4 is polymorphic and the number of Ser varies in the population (from 8 to 17). The variation might be associated with tumorigenesis.,PTM:Differentially phosphorylated in vivo.,similarity:Belongs to the E2F/DP family.,subunit:Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. The E2F4/DP-1 dimer interacts preferentially with pocket protein RBL1, which inhibits the E2F transactivation domain. Lower affinity interaction has been found with retinoblastoma protein RB1. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Interacts with HCFC1. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.,tissue specificity:Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus.
組織表達： Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
科研貨號： PLN000025

E2F-4 (Acetyl Lys96) Polyclonal Antibody

Catalog No PLN000025

Product information

基因名稱： E2F4
蛋白名稱： Transcription factor E2F4
Human_gene_id： 1874
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1874
Human_swiss_prot_no： Q16254
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q16254/entry
Mouse_gene_id： 104394
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=104394
Mouse_swiss_prot_no： Q8R0K9
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8R0K9
特異性： Acetyl-E2F-4 (K96) Polyclonal Antibody detects endogenous levels of E2F-4 protein only when acetylated at K96.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： E2F4; Transcription factor E2F4; E2F-4
實測條帶： 43kD
信號通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;TGF-beta;
功能： developmental stage:Present in the growth-arrested state, its abundance does not change significantly as cells move into and through the cell cycle.,function:Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-4 binds with high affinity to RBL1 and RBL2. In some instances, can also bind RB protein.,polymorphism:The poly-Ser region of E2F4 is polymorphic and the number of Ser varies in the population (from 8 to 17). The variation might be associated with tumorigenesis.,PTM:Differentially phosphorylated in vivo.,similarity:Belongs to the E2F/DP family.,subunit:Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. The E2F4/DP-1 dimer interacts preferentially with pocket protein RBL1, which inhibits the E2F transactivation domain. Lower affinity interaction has been found with retinoblastoma protein RB1. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Interacts with HCFC1. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.,tissue specificity:Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus.
組織表達： Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
科研貨號： PLN000025

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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