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YTDC1 rabbit pAb

商品貨號： PLA021554

適應(yīng) 性： 人,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

在線咨詢

MSDS

說明書

商品描述

基因名稱： YTHDC1 KIAA1966 YT521
蛋白名稱： YTH domain-containing protein 1 (Putative splicing factor YT521)
Human_gene_id： 91746
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=91746
Human_swiss_prot_no： Q96MU7
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q96MU7/entry
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=0
Rat_gene_id： 170956
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170956
Rat_swiss_prot_no： Q9QY02
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q9QY02/entry
特異性： This antibody detects endogenous levels of YTDC1 at Human,Rat
組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000 IHC 1:50-200
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： YTH domain-containing protein 1 (Putative splicing factor YT521)
分子量： 80kD
功能： Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability . Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 . Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing . In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May also regulate alternative splice site selection . Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export . Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules . Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist . Also recognizes and binds m6A-containing single-stranded DNA . Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity).
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Nucleus speckle . Localizes to a novel subnuclear structure, the YT bodies. .
科研貨號： PLA021554

YTDC1 rabbit pAb

Catalog No PLA021554

Product information

基因名稱： YTHDC1 KIAA1966 YT521
蛋白名稱： YTH domain-containing protein 1 (Putative splicing factor YT521)
Human_gene_id： 91746
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=91746
Human_swiss_prot_no： Q96MU7
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q96MU7/entry
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=0
Rat_gene_id： 170956
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170956
Rat_swiss_prot_no： Q9QY02
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q9QY02/entry
特異性： This antibody detects endogenous levels of YTDC1 at Human,Rat
組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000 IHC 1:50-200
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： YTH domain-containing protein 1 (Putative splicing factor YT521)
分子量： 80kD
功能： Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability . Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 . Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing . In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May also regulate alternative splice site selection . Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export . Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules . Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist . Also recognizes and binds m6A-containing single-stranded DNA . Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity).
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Nucleus speckle . Localizes to a novel subnuclear structure, the YT bodies. .
科研貨號： PLA021554

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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