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TET2 rabbit pAb

商品貨號(hào)： PLA021537

適應(yīng) 性： 人,小鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書

商品描述

基因名稱： TET2 KIAA1546 Nbla00191
蛋白名稱： Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
Human_gene_id： 54790
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54790
Human_swiss_prot_no： Q6N021
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q6N021/entry
Mouse_gene_id： 214133
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=214133
Mouse_swiss_prot_no： Q4JK59
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q4JK59/entry
特異性： This antibody detects endogenous levels of TET2 at Human, Mouse
組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000 IHC 1:50-200
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
分子量： 220kD
功能： Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
組織表達(dá)： Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes.
科研貨號(hào)： PLA021537

TET2 rabbit pAb

Catalog No PLA021537

Product information

基因名稱： TET2 KIAA1546 Nbla00191
蛋白名稱： Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
Human_gene_id： 54790
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54790
Human_swiss_prot_no： Q6N021
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q6N021/entry
Mouse_gene_id： 214133
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=214133
Mouse_swiss_prot_no： Q4JK59
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q4JK59/entry
特異性： This antibody detects endogenous levels of TET2 at Human, Mouse
組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000 IHC 1:50-200
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
分子量： 220kD
功能： Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
組織表達(dá)： Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes.
科研貨號(hào)： PLA021537

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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