2021韩国R级在线播放,中文字幕一区亚洲高清,欧美综合自拍另类图库,2020国偷自产一区,最近好看视频2018中文字幕,sm电击调教痉挛在线视频VIP

亚洲国产日韩不卡综合,明星ai换脸磁力资源种子搜索,成人性闻CCAV下载,欧美日本国产在线a小说v,亚洲欧洲综合一区二区三区,里中结衣av中文字幕

> > > >

TOPBP1 rabbit pAb

商品貨號： PLA021469

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

在線咨詢

MSDS

說明書

商品描述

發(fā)貨日期： 14
基因名稱： TOPBP1 KIAA0259
蛋白名稱： TOPBP1
Human_gene_id： 11073
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11073
Human_swiss_prot_no： Q92547
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q92547/entry
Mouse_gene_id： 235559
Mouse_gene_link： https://www.uniprot.org/uniprot/235559
Mouse_swiss_prot_no： Q6ZQF0
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q6ZQF0
Rat_swiss_link： https://www.uniprot.org/uniprotkb/0
特異性： This antibody detects endogenous levels of TOPBP1 at Human, Mouse,Rat
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
分子量： 167kD
功能： function:Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.,induction:Up-regulated during the S phase of the cell cycle. Up-regulated by E2F1 and interferon.,PTM:Phosphorylated on serine and threonine residues in response to X-ray irradiation.,PTM:Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination.,similarity:Contains 8 BRCT domains.,subcellular location:Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation.,subunit:Binds E2F1, PML, RAD9A, SMARCA2, SMARCA4, POLE and UBR5. May interact with TOP2B.,tissue specificity:Highly expressed in heart, brain, placenta, lung and kidney.,
細胞定位： Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. .
組織表達： Highly expressed in heart, brain, placenta, lung and kidney.
科研貨號： PLA021469

TOPBP1 rabbit pAb

Catalog No PLA021469

Product information

發(fā)貨日期： 14
基因名稱： TOPBP1 KIAA0259
蛋白名稱： TOPBP1
Human_gene_id： 11073
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11073
Human_swiss_prot_no： Q92547
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q92547/entry
Mouse_gene_id： 235559
Mouse_gene_link： https://www.uniprot.org/uniprot/235559
Mouse_swiss_prot_no： Q6ZQF0
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q6ZQF0
Rat_swiss_link： https://www.uniprot.org/uniprotkb/0
特異性： This antibody detects endogenous levels of TOPBP1 at Human, Mouse,Rat
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
分子量： 167kD
功能： function:Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.,induction:Up-regulated during the S phase of the cell cycle. Up-regulated by E2F1 and interferon.,PTM:Phosphorylated on serine and threonine residues in response to X-ray irradiation.,PTM:Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination.,similarity:Contains 8 BRCT domains.,subcellular location:Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation.,subunit:Binds E2F1, PML, RAD9A, SMARCA2, SMARCA4, POLE and UBR5. May interact with TOP2B.,tissue specificity:Highly expressed in heart, brain, placenta, lung and kidney.,
細胞定位： Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. .
組織表達： Highly expressed in heart, brain, placenta, lung and kidney.
科研貨號： PLA021469

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

亚洲国产日韩不卡综合,明星ai换脸磁力资源种子搜索,成人性闻CCAV下载,欧美日本国产在线a小说v,亚洲欧洲综合一区二区三区,里中结衣av中文字幕