功能: domain:The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.,function:Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy.,similarity:Belongs to the ATG7 family.,subunit:Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.,tissue specificity:Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3373
細(xì)胞定位: Cytoplasm . Preautophagosomal structure . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .
組織表達(dá): Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
功能: domain:The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.,function:Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy.,similarity:Belongs to the ATG7 family.,subunit:Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.,tissue specificity:Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3373
細(xì)胞定位: Cytoplasm . Preautophagosomal structure . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .
組織表達(dá): Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
tag: hot
科研貨號: PLA021355
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