其他名稱: Vascular cell adhesion protein 1 (V-CAM 1;VCAM-1;INCAM-100;CD antigen CD106)
分子量: 81kD
功能: alternative products:Additional isoforms seem to exist,disease:May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.,domain:Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.,function:Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.,induction:By cytokines (e.g. IL-1, TNF-alpha).,online information:VCAM-1,online information:VCAM1 entry,PTM:Sialoglycoprotein.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to ECMV-D capsid proteins and acts as a receptor for this virus.,tissue specificity:Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3324
細胞定位: Membrane; Single-pass type I membrane protein.
組織表達: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
其他名稱: Vascular cell adhesion protein 1 (V-CAM 1;VCAM-1;INCAM-100;CD antigen CD106)
分子量: 81kD
功能: alternative products:Additional isoforms seem to exist,disease:May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.,domain:Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.,function:Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.,induction:By cytokines (e.g. IL-1, TNF-alpha).,online information:VCAM-1,online information:VCAM1 entry,PTM:Sialoglycoprotein.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to ECMV-D capsid proteins and acts as a receptor for this virus.,tissue specificity:Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3324
細胞定位: Membrane; Single-pass type I membrane protein.
組織表達: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
tag: hot
科研貨號: PLA021310
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