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WRN rabbit pAb

商品貨號： PLA021277

適應(yīng) 性： 人,大鼠,小鼠,

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： WRN RECQ3 RECQL2
蛋白名稱： WRN
Human_gene_id： 7486
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7486
Human_swiss_prot_no： Q14191
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q14191/entry
Mouse_gene_id： 22427
Mouse_gene_link： https://www.uniprot.org/uniprot/22427
Mouse_swiss_prot_no： O09053
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/O09053
特異性： This antibody detects endogenous levels of Human WRN
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Werner syndrome ATP-dependent helicase (EC 3.6.4.12;DNA helicase, RecQ-like type 3;RecQ3;Exonuclease WRN;EC 3.1.-.-;RecQ protein-like 2)
分子量： 158kD
功能： disease:Defects in WRN are a cause of Werner syndrome (WRN) [MIM:277700]. WRN is a rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. Currently all known WS mutations produces prematurely terminated proteins.,disease:Defects in WRN may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability.,online information:WRN mutation db (Warner disease),PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the helicase family. RecQ subfamily.,similarity:Contains 1 3'-5' exonuclease domain.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 HRDC domain.,subunit:Interacts via its N-terminal domain with WRNIP1 (By similarity). Interacts with EXO1.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3289
細(xì)胞定位： Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Chromosome . Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). .
科研貨號： PLA021277

WRN rabbit pAb

Catalog No PLA021277

Product information

基因名稱： WRN RECQ3 RECQL2
蛋白名稱： WRN
Human_gene_id： 7486
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7486
Human_swiss_prot_no： Q14191
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q14191/entry
Mouse_gene_id： 22427
Mouse_gene_link： https://www.uniprot.org/uniprot/22427
Mouse_swiss_prot_no： O09053
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/O09053
特異性： This antibody detects endogenous levels of Human WRN
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Werner syndrome ATP-dependent helicase (EC 3.6.4.12;DNA helicase, RecQ-like type 3;RecQ3;Exonuclease WRN;EC 3.1.-.-;RecQ protein-like 2)
分子量： 158kD
功能： disease:Defects in WRN are a cause of Werner syndrome (WRN) [MIM:277700]. WRN is a rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. Currently all known WS mutations produces prematurely terminated proteins.,disease:Defects in WRN may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability.,online information:WRN mutation db (Warner disease),PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the helicase family. RecQ subfamily.,similarity:Contains 1 3'-5' exonuclease domain.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 HRDC domain.,subunit:Interacts via its N-terminal domain with WRNIP1 (By similarity). Interacts with EXO1.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3289
細(xì)胞定位： Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Chromosome . Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). .
科研貨號： PLA021277

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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