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STABP rabbit pAb

商品貨號： PLA021222

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： STAMBP AMSH
蛋白名稱： STABP
Human_gene_id： 10617
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10617
Human_swiss_prot_no： O95630
Human_swiss_link： https://www.uniprot.org/uniprotkb/O95630/entry
Mouse_gene_id： 70527
Mouse_gene_link： https://www.uniprot.org/uniprot/70527
Mouse_swiss_prot_no： Q9CQ26
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q9CQ26
Rat_gene_id： 171565
Rat_gene_link： https://www.uniprot.org/uniprot/171565
Rat_swiss_prot_no： Q8R424
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q8R424
特異性： This antibody detects endogenous levels of STABP at Human/Mouse/Rat
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1：500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
分子量： 47kD
功能： catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,cofactor:Binds 2 zinc ion per subunit.,domain:The JAMM motif is essential for the protease activity.,enzyme regulation:Inhibited by N-ethylmaleimide.,function:Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.,miscellaneous:X-ray crystallography studies of STAMBPL1, another member of the peptidase M67C family, has shown that Glu-280 binds zinc indirectly via a water molecule. Nevertheless, this residue is essential for catalytic activity.,PTM:Phosphorylated after BMP type I receptor activation.,similarity:Belongs to the peptidase M67C family.,similarity:Contains 1 MPN (JAB/Mov34) domain.,subunit:Interacts with STAM1. Interacts with SMAD6 and SMAD7. Interacts with CHMP3; the interaction appears to relieve the autoinhibition of CHMP3.,tissue specificity:Ubiquitously expressed.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
組織表達(dá)： Ubiquitously expressed.
科研貨號： PLA021222

STABP rabbit pAb

Catalog No PLA021222

Product information

基因名稱： STAMBP AMSH
蛋白名稱： STABP
Human_gene_id： 10617
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10617
Human_swiss_prot_no： O95630
Human_swiss_link： https://www.uniprot.org/uniprotkb/O95630/entry
Mouse_gene_id： 70527
Mouse_gene_link： https://www.uniprot.org/uniprot/70527
Mouse_swiss_prot_no： Q9CQ26
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q9CQ26
Rat_gene_id： 171565
Rat_gene_link： https://www.uniprot.org/uniprot/171565
Rat_swiss_prot_no： Q8R424
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q8R424
特異性： This antibody detects endogenous levels of STABP at Human/Mouse/Rat
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1：500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
分子量： 47kD
功能： catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,cofactor:Binds 2 zinc ion per subunit.,domain:The JAMM motif is essential for the protease activity.,enzyme regulation:Inhibited by N-ethylmaleimide.,function:Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.,miscellaneous:X-ray crystallography studies of STAMBPL1, another member of the peptidase M67C family, has shown that Glu-280 binds zinc indirectly via a water molecule. Nevertheless, this residue is essential for catalytic activity.,PTM:Phosphorylated after BMP type I receptor activation.,similarity:Belongs to the peptidase M67C family.,similarity:Contains 1 MPN (JAB/Mov34) domain.,subunit:Interacts with STAM1. Interacts with SMAD6 and SMAD7. Interacts with CHMP3; the interaction appears to relieve the autoinhibition of CHMP3.,tissue specificity:Ubiquitously expressed.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
組織表達(dá)： Ubiquitously expressed.
科研貨號： PLA021222

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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