功能: cofactor:Binds 2 heme groups non-covalently.,disease:Defects in CYBRD1 may be a cause of primary hereditary hemochromatosis (HFE). HFE is an iron-loading disorder characterized by iron accumulation in parenchymal cells. Iron accumulation usually results in tissue damage and causes cirrhosis of the liver, diabetes mellitus, arthropathy, cardiomyopathy, endocrine abnormalities and an increased risk of hepatocellular carcinoma.,function:Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.,induction:By iron deficiency (at protein level).,similarity:Contains 1 cytochrome b561 domain.,tissue specificity:Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細(xì)胞定位: Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Localized at the brush border of duodenal cells. .
組織表達(dá): Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.
功能: cofactor:Binds 2 heme groups non-covalently.,disease:Defects in CYBRD1 may be a cause of primary hereditary hemochromatosis (HFE). HFE is an iron-loading disorder characterized by iron accumulation in parenchymal cells. Iron accumulation usually results in tissue damage and causes cirrhosis of the liver, diabetes mellitus, arthropathy, cardiomyopathy, endocrine abnormalities and an increased risk of hepatocellular carcinoma.,function:Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.,induction:By iron deficiency (at protein level).,similarity:Contains 1 cytochrome b561 domain.,tissue specificity:Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細(xì)胞定位: Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Localized at the brush border of duodenal cells. .
組織表達(dá): Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.
科研貨號(hào): PLA021103
Hunan UPT Biotechnology Co.,Ltd
Website:m.tjdqdt.com Servive hotline :4006916686
E-mail:service@uptbio.com
Address:
Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road,
Yuelu District, Changsha City, Hunan Province, China.