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CBX4 rabbit pAb

商品貨號(hào)： PLA021082

適應(yīng) 性： 人,小鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： CBX4
蛋白名稱： CBX4
Human_gene_id： 8535
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8535
Human_swiss_prot_no： O00257
Human_swiss_link： https://www.uniprot.org/uniprotkb/O00257/entry
Mouse_gene_id： 12418
Mouse_gene_link： https://www.uniprot.org/uniprot/12418
Mouse_swiss_prot_no： O55187
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/O55187
特異性： This antibody detects endogenous levels of CBX4 at Human/Mouse
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1：500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
分子量： 62kD
功能： function:E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.,pathway:Protein modification; protein sumoylation.,PTM:Phosphorylated on Thr-495 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-492.,similarity:Contains 1 chromo domain.,subunit:Interacts with histone H3-K9Me3 (By similarity). Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Interacts with SUV39H1 and HIPK2.,tissue specificity:Ubiquitous.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Nucleus speckle . Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235). .
組織表達(dá)： Ubiquitous.
科研貨號(hào)： PLA021082

CBX4 rabbit pAb

Catalog No PLA021082

Product information

基因名稱： CBX4
蛋白名稱： CBX4
Human_gene_id： 8535
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8535
Human_swiss_prot_no： O00257
Human_swiss_link： https://www.uniprot.org/uniprotkb/O00257/entry
Mouse_gene_id： 12418
Mouse_gene_link： https://www.uniprot.org/uniprot/12418
Mouse_swiss_prot_no： O55187
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/O55187
特異性： This antibody detects endogenous levels of CBX4 at Human/Mouse
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1：500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
分子量： 62kD
功能： function:E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.,pathway:Protein modification; protein sumoylation.,PTM:Phosphorylated on Thr-495 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-492.,similarity:Contains 1 chromo domain.,subunit:Interacts with histone H3-K9Me3 (By similarity). Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Interacts with SUV39H1 and HIPK2.,tissue specificity:Ubiquitous.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Nucleus speckle . Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235). .
組織表達(dá)： Ubiquitous.
科研貨號(hào)： PLA021082

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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