功能: disease:Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.,function:May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.,induction:By nitric oxide and DMSO in HL60 cells, an acute myeloid leukemia cell line.,similarity:Belongs to the NLRP family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Binds to ASC with its DAPIN domain.,tissue specificity:Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細(xì)胞定位: Cytoplasm .
組織表達(dá): Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
功能: disease:Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.,function:May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.,induction:By nitric oxide and DMSO in HL60 cells, an acute myeloid leukemia cell line.,similarity:Belongs to the NLRP family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Binds to ASC with its DAPIN domain.,tissue specificity:Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細(xì)胞定位: Cytoplasm .
組織表達(dá): Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
tag: hot
科研貨號(hào): PLA021067
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