功能: domain:The C2 domains are not involved in calcium-dependent phospholipid binding.,function:Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.,similarity:Belongs to the unc-13 family.,similarity:Contains 1 MHD1 (MUNC13 homology domain 1) domain.,similarity:Contains 1 MHD2 (MUNC13 homology domain 2) domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 3 C2 domains.,subcellular location:Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.,subunit:Interacts with RIMS1.,tissue specificity:Expressed in kidney cortical epithelial cells and brain.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細胞定位: Cytoplasm . Membrane ; Peripheral membrane protein . Cell membrane . Cell junction, synapse . Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). .
組織表達: Expressed in kidney cortical epithelial cells and brain.
功能: domain:The C2 domains are not involved in calcium-dependent phospholipid binding.,function:Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.,similarity:Belongs to the unc-13 family.,similarity:Contains 1 MHD1 (MUNC13 homology domain 1) domain.,similarity:Contains 1 MHD2 (MUNC13 homology domain 2) domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 3 C2 domains.,subcellular location:Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.,subunit:Interacts with RIMS1.,tissue specificity:Expressed in kidney cortical epithelial cells and brain.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細胞定位: Cytoplasm . Membrane ; Peripheral membrane protein . Cell membrane . Cell junction, synapse . Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). .
組織表達: Expressed in kidney cortical epithelial cells and brain.
科研貨號: PLA020620
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