功能: function:Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.,miscellaneous:Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.,similarity:Contains 1 SAC domain.,tissue specificity:Ubiquitous.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細(xì)胞定位: Membrane, clathrin-coated pit . Early endosome . Recycling endosome . Also found on macropinosomes. .
組織表達(dá): Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).
功能: function:Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.,miscellaneous:Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.,similarity:Contains 1 SAC domain.,tissue specificity:Ubiquitous.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細(xì)胞定位: Membrane, clathrin-coated pit . Early endosome . Recycling endosome . Also found on macropinosomes. .
組織表達(dá): Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).
科研貨號: PLA020595
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