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RFX5 rabbit pAb

商品貨號(hào)： PLA020552

適應(yīng) 性： 人,小鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書

商品描述

基因名稱： RFX5
蛋白名稱： RFX5
Human_gene_id： 5993
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5993
Human_swiss_prot_no： P48382
Human_swiss_link： https://www.uniprot.org/uniprotkb/P48382/entry
Mouse_gene_id： 53970
Mouse_gene_link： https://www.uniprot.org/uniprot/53970
Mouse_swiss_prot_no： Q9JL61
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q9JL61
特異性： This antibody detects endogenous levels of RFX5 at Human/Mouse
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
分子量： 68kD
功能： disease:Defects in RFX5 are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.,domain:The N-terminus is required for its association with RFXANK and RFXAP, for assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperative binding between the RFX complex and NF-Y.,function:Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.,online information:RFX5 mutation db,PTM:Phosphorylated.,similarity:Belongs to the RFX family.,subunit:RFX consists of at least three different subunits; RFXAP, RFX5 and RFX-B/RFXANK; with each subunit representing a separate complementation group. RFX forms cooperative DNA binding complexes with X2BP and CBF/NF-Y. RFX associates with CIITA to form an active transcriptional complex.,tissue specificity:Ubiquitous.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus.
組織表達(dá)： Ubiquitous.
科研貨號(hào)： PLA020552

RFX5 rabbit pAb

Catalog No PLA020552

Product information

基因名稱： RFX5
蛋白名稱： RFX5
Human_gene_id： 5993
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5993
Human_swiss_prot_no： P48382
Human_swiss_link： https://www.uniprot.org/uniprotkb/P48382/entry
Mouse_gene_id： 53970
Mouse_gene_link： https://www.uniprot.org/uniprot/53970
Mouse_swiss_prot_no： Q9JL61
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q9JL61
特異性： This antibody detects endogenous levels of RFX5 at Human/Mouse
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
分子量： 68kD
功能： disease:Defects in RFX5 are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.,domain:The N-terminus is required for its association with RFXANK and RFXAP, for assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperative binding between the RFX complex and NF-Y.,function:Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.,online information:RFX5 mutation db,PTM:Phosphorylated.,similarity:Belongs to the RFX family.,subunit:RFX consists of at least three different subunits; RFXAP, RFX5 and RFX-B/RFXANK; with each subunit representing a separate complementation group. RFX forms cooperative DNA binding complexes with X2BP and CBF/NF-Y. RFX associates with CIITA to form an active transcriptional complex.,tissue specificity:Ubiquitous.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus.
組織表達(dá)： Ubiquitous.
科研貨號(hào)： PLA020552

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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