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CHMP6 rabbit pAb

商品貨號： PLA020528

適應性： 人,小鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： CHMP6 VPS20
蛋白名稱： CHMP6
Human_gene_id： 79643
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79643
Human_swiss_prot_no： Q96FZ7
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q96FZ7/entry
Mouse_gene_id： 208092
Mouse_gene_link： https://www.uniprot.org/uniprot/208092
Mouse_swiss_prot_no： P0C0A3
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P0C0A3
特異性： This antibody detects endogenous levels of CHMP6 at Human/Mouse
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1：500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
分子量： 22kD
功能： domain:The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.,function:Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.,similarity:Belongs to the SNF7 family.,subcellular location:Localizes to endosomal membranes.,subunit:Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP4A, CHMP4B and CHMP4C. Interacts with SNF8, VPS25 and VPS36.,tissue specificity:Ubiquitously expressed.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane . Membrane ; Lipid-anchor . Localizes to endosomal membranes.
組織表達： Ubiquitously expressed.
科研貨號： PLA020528

CHMP6 rabbit pAb

Catalog No PLA020528

Product information

基因名稱： CHMP6 VPS20
蛋白名稱： CHMP6
Human_gene_id： 79643
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79643
Human_swiss_prot_no： Q96FZ7
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q96FZ7/entry
Mouse_gene_id： 208092
Mouse_gene_link： https://www.uniprot.org/uniprot/208092
Mouse_swiss_prot_no： P0C0A3
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P0C0A3
特異性： This antibody detects endogenous levels of CHMP6 at Human/Mouse
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1：500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
分子量： 22kD
功能： domain:The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.,function:Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.,similarity:Belongs to the SNF7 family.,subcellular location:Localizes to endosomal membranes.,subunit:Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP4A, CHMP4B and CHMP4C. Interacts with SNF8, VPS25 and VPS36.,tissue specificity:Ubiquitously expressed.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane . Membrane ; Lipid-anchor . Localizes to endosomal membranes.
組織表達： Ubiquitously expressed.
科研貨號： PLA020528

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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