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KIF5A rabbit pAb

商品貨號(hào)： PLA020522

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： KIF5A NKHC1
蛋白名稱： KIF5A
Human_gene_id： 3798
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3798
Human_swiss_prot_no： Q12840
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q12840/entry
Mouse_gene_id： 16572
Mouse_gene_link： https://www.uniprot.org/uniprot/16572
Mouse_swiss_prot_no： P33175
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P33175
Rat_gene_id： 314906
Rat_gene_link： https://www.uniprot.org/uniprot/314906
Rat_swiss_prot_no： Q6QLM7
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q6QLM7
特異性： This antibody detects endogenous levels of KIF5A at Human/Mouse/Rat
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
分子量： 114kD
功能： disease:Defects in KIF5A are the cause of spastic paraplegia type 10 (SPG10) [MIM:604187]. SPG10 is a form of autosomal dominant hereditary spastic paraplegia (AD-HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.,domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,function:Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subcellular location:Concentrated in the cell body of the neurons, particularly in the perinuclear region.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1.,tissue specificity:Distributed throughout the CNS but is highly enriched in subsets of neurons.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Perikaryon . Concentrated in the cell body of the neurons, particularly in the perinuclear region. .
組織表達(dá)： Distributed throughout the CNS but is highly enriched in subsets of neurons.
科研貨號(hào)： PLA020522

KIF5A rabbit pAb

Catalog No PLA020522

Product information

基因名稱： KIF5A NKHC1
蛋白名稱： KIF5A
Human_gene_id： 3798
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3798
Human_swiss_prot_no： Q12840
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q12840/entry
Mouse_gene_id： 16572
Mouse_gene_link： https://www.uniprot.org/uniprot/16572
Mouse_swiss_prot_no： P33175
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P33175
Rat_gene_id： 314906
Rat_gene_link： https://www.uniprot.org/uniprot/314906
Rat_swiss_prot_no： Q6QLM7
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q6QLM7
特異性： This antibody detects endogenous levels of KIF5A at Human/Mouse/Rat
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
分子量： 114kD
功能： disease:Defects in KIF5A are the cause of spastic paraplegia type 10 (SPG10) [MIM:604187]. SPG10 is a form of autosomal dominant hereditary spastic paraplegia (AD-HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.,domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,function:Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subcellular location:Concentrated in the cell body of the neurons, particularly in the perinuclear region.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1.,tissue specificity:Distributed throughout the CNS but is highly enriched in subsets of neurons.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Perikaryon . Concentrated in the cell body of the neurons, particularly in the perinuclear region. .
組織表達(dá)： Distributed throughout the CNS but is highly enriched in subsets of neurons.
科研貨號(hào)： PLA020522

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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