功能: catalytic activity:The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.,function:May participate in both nuclear and mitochondrial post-replicative base excision repair (BER). In the nucleus functions in the PCNA-dependent BER pathway.,similarity:Belongs to the DNA repair enzymes AP/exoA family.,subcellular location:Colocalized partly with PCNA in nuclear foci.,subunit:Interacts with PCNA. This interaction is increased by misincorporation of uracil in nuclear DNA.,tissue specificity:Highly expressed in cells, adult brain and kidney. Weakly expressed in the fetal brain.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細胞定位: Nucleus. Cytoplasm. Mitochondrion . Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
組織表達: Highly expressed in brain and kidney. Weakly expressed in the fetal brain.
功能: catalytic activity:The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.,function:May participate in both nuclear and mitochondrial post-replicative base excision repair (BER). In the nucleus functions in the PCNA-dependent BER pathway.,similarity:Belongs to the DNA repair enzymes AP/exoA family.,subcellular location:Colocalized partly with PCNA in nuclear foci.,subunit:Interacts with PCNA. This interaction is increased by misincorporation of uracil in nuclear DNA.,tissue specificity:Highly expressed in cells, adult brain and kidney. Weakly expressed in the fetal brain.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細胞定位: Nucleus. Cytoplasm. Mitochondrion . Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
組織表達: Highly expressed in brain and kidney. Weakly expressed in the fetal brain.
科研貨號: PLA020199
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