功能： caution:Was originally (PubMed:7507208) thought to have protein tyrosine kinase activity.,function:Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.,online information:Molecular embrace -Issue 73 of August 2006,PTM:Phosphorylated on serine and threonine residues.,similarity:Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.,similarity:Contains 2 ADF-H domains.,subcellular location:Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.,subunit:Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated.,tissue specificity:Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Cytoplasm. Cytoplasm, cytoskeleton . Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). .
組織表達： Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
功能： caution:Was originally (PubMed:7507208) thought to have protein tyrosine kinase activity.,function:Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.,online information:Molecular embrace -Issue 73 of August 2006,PTM:Phosphorylated on serine and threonine residues.,similarity:Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.,similarity:Contains 2 ADF-H domains.,subcellular location:Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.,subunit:Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated.,tissue specificity:Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Cytoplasm. Cytoplasm, cytoskeleton . Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). .
組織表達： Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
科研貨號： PLA020171
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