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AK1D1 rabbit pAb

商品貨號(hào)： PLA020014

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

基因名稱： AKR1D1 SRD5B1
蛋白名稱： AK1D1
Human_gene_id： 6718
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6718
Human_swiss_prot_no： P51857
Human_swiss_link： https://www.uniprot.org/uniprotkb/P51857/entry
Mouse_gene_id： 208665
Mouse_gene_link： https://www.uniprot.org/uniprot/208665
Mouse_swiss_prot_no： Q8VCX1
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q8VCX1
Rat_gene_id： 192242
Rat_gene_link： https://www.uniprot.org/uniprot/192242
Rat_swiss_prot_no： P31210
Rat_swiss_link： https://www.uniprot.org/uniprotkb/P31210
特異性： This antibody detects endogenous levels of AK1D1 at Human/Mouse/Rat
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1：500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
分子量： 36kD
功能： catalytic activity:17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone.,catalytic activity:5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH.,disease:Defects in AKR1D1 are the cause of congenital bile acid synthesis defect type 2 (CBAS2) [MIM:235555]; also known as cholestasis with delta(4)-3-oxosteroid 5-beta-reductase deficiency. Patients with this liver disease show absence or low levels of chenodeoxycholic acid and cholic acid in plasma and urine.,enzyme regulation:Subject to inhibition by high substrate concentrations. Inhibited by testosterone concentrations above 10 uM.,function:Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.,similarity:Belongs to the aldo/keto reductase family.,tissue specificity:Highly expressed in liver. Expressed in testis and weakly in colon.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm .
組織表達(dá)： Highly expressed in liver. Expressed in testis and weakly in colon.
科研貨號(hào)： PLA020014

AK1D1 rabbit pAb

Catalog No PLA020014

Product information

基因名稱： AKR1D1 SRD5B1
蛋白名稱： AK1D1
Human_gene_id： 6718
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6718
Human_swiss_prot_no： P51857
Human_swiss_link： https://www.uniprot.org/uniprotkb/P51857/entry
Mouse_gene_id： 208665
Mouse_gene_link： https://www.uniprot.org/uniprot/208665
Mouse_swiss_prot_no： Q8VCX1
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q8VCX1
Rat_gene_id： 192242
Rat_gene_link： https://www.uniprot.org/uniprot/192242
Rat_swiss_prot_no： P31210
Rat_swiss_link： https://www.uniprot.org/uniprotkb/P31210
特異性： This antibody detects endogenous levels of AK1D1 at Human/Mouse/Rat
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1：500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
分子量： 36kD
功能： catalytic activity:17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone.,catalytic activity:5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH.,disease:Defects in AKR1D1 are the cause of congenital bile acid synthesis defect type 2 (CBAS2) [MIM:235555]; also known as cholestasis with delta(4)-3-oxosteroid 5-beta-reductase deficiency. Patients with this liver disease show absence or low levels of chenodeoxycholic acid and cholic acid in plasma and urine.,enzyme regulation:Subject to inhibition by high substrate concentrations. Inhibited by testosterone concentrations above 10 uM.,function:Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.,similarity:Belongs to the aldo/keto reductase family.,tissue specificity:Highly expressed in liver. Expressed in testis and weakly in colon.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm .
組織表達(dá)： Highly expressed in liver. Expressed in testis and weakly in colon.
科研貨號(hào)： PLA020014

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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