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FBW1B rabbit pAb

商品貨號： PLA019824

適應(yīng) 性： 人,小鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： FBXW11 BTRCP2 FBW1B FBXW1B KIAA0696
蛋白名稱： FBW1B
Human_gene_id： 23291
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23291
Human_swiss_prot_no： Q9UKB1
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9UKB1/entry
Mouse_gene_id： 103583
Mouse_gene_link： https://www.uniprot.org/uniprot/103583
Mouse_swiss_prot_no： Q5SRY7
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q5SRY7
特異性： This antibody detects endogenous levels of FBW1B at Human/Mouse
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1：500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
分子量： 60kD
功能： function:Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of NFKBIA, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1.,similarity:Contains 1 F-box domain.,similarity:Contains 7 WD repeats.,subunit:Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1A, RBX1 and a FBXW11 dimer. Interacts with BTRC. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1; the interaction requires the phosphorylation of the two serine residues in the destruction motif D-S-G-X(2,3)-S.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus .
科研貨號： PLA019824

FBW1B rabbit pAb

Catalog No PLA019824

Product information

基因名稱： FBXW11 BTRCP2 FBW1B FBXW1B KIAA0696
蛋白名稱： FBW1B
Human_gene_id： 23291
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23291
Human_swiss_prot_no： Q9UKB1
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9UKB1/entry
Mouse_gene_id： 103583
Mouse_gene_link： https://www.uniprot.org/uniprot/103583
Mouse_swiss_prot_no： Q5SRY7
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q5SRY7
特異性： This antibody detects endogenous levels of FBW1B at Human/Mouse
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1：500-2000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
分子量： 60kD
功能： function:Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of NFKBIA, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1.,similarity:Contains 1 F-box domain.,similarity:Contains 7 WD repeats.,subunit:Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1A, RBX1 and a FBXW11 dimer. Interacts with BTRC. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1; the interaction requires the phosphorylation of the two serine residues in the destruction motif D-S-G-X(2,3)-S.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus .
科研貨號： PLA019824

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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