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PON1 Polyclonal Antibody

商品貨號(hào)： PLA019543

適應(yīng) 性： 人,大鼠,小鼠,

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： PON1 PON
蛋白名稱： Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)
Human_gene_id： 5444
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5444
Human_swiss_prot_no： P27169
Human_swiss_link： http://www.uniprot.org/uniprotkb/P27169/entry
Mouse_gene_id： 18979
Mouse_swiss_prot_no： P52430
Mouse_swiss_link： http://www.uniprot.org/uniprot/P52430
特異性： The antibody detects endogenous PON1
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Serum paraoxonase/arylesterase 1 (PON 1;EC 3.1.1.2;EC 3.1.1.81;EC 3.1.8.1;Aromatic esterase 1;A-esterase 1;K-45;Serum aryldialkylphosphatase 1)
功能： catalytic activity:A phenyl acetate + H(2)O = a phenol + acetate.,catalytic activity:An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.,disease:Genetic variation in PON1 is associated with susceptibility to diabetic retinopathy [MIM:612633]; also called microvascular complications of diabetes type 5 (MVCD5). Diabetic retinopathy is a major cause of blindness in diabetic patients. Retinal disease results from adverse effects on the blood vessels which supply the retina.,function:Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. May mediate an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.,miscellaneous:The preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces.,online information:The Singapore human mutation and polymorphism database,polymorphism:The allelic form of the enzyme with Gln-192 (allozyme A) hydrolyzes paraoxon with a low turnover number and the one with Arg-192 (allozyme B) with a high turnover number.,PTM:Glycosylated.,PTM:Present in two forms, form B contains a disulfide bond, form A does not.,PTM:The signal sequence is not cleaved.,similarity:Belongs to the paraoxonase family.,subunit:Heterooligomer with phosphate-binding protein (HPBP). Interacts with CLU.,tissue specificity:Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Secreted, extracellular space.
組織表達(dá)： Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
科研貨號(hào)： PLA019543

PON1 Polyclonal Antibody

Catalog No PLA019543

Product information

基因名稱： PON1 PON
蛋白名稱： Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)
Human_gene_id： 5444
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5444
Human_swiss_prot_no： P27169
Human_swiss_link： http://www.uniprot.org/uniprotkb/P27169/entry
Mouse_gene_id： 18979
Mouse_swiss_prot_no： P52430
Mouse_swiss_link： http://www.uniprot.org/uniprot/P52430
特異性： The antibody detects endogenous PON1
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Serum paraoxonase/arylesterase 1 (PON 1;EC 3.1.1.2;EC 3.1.1.81;EC 3.1.8.1;Aromatic esterase 1;A-esterase 1;K-45;Serum aryldialkylphosphatase 1)
功能： catalytic activity:A phenyl acetate + H(2)O = a phenol + acetate.,catalytic activity:An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.,disease:Genetic variation in PON1 is associated with susceptibility to diabetic retinopathy [MIM:612633]; also called microvascular complications of diabetes type 5 (MVCD5). Diabetic retinopathy is a major cause of blindness in diabetic patients. Retinal disease results from adverse effects on the blood vessels which supply the retina.,function:Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. May mediate an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.,miscellaneous:The preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces.,online information:The Singapore human mutation and polymorphism database,polymorphism:The allelic form of the enzyme with Gln-192 (allozyme A) hydrolyzes paraoxon with a low turnover number and the one with Arg-192 (allozyme B) with a high turnover number.,PTM:Glycosylated.,PTM:Present in two forms, form B contains a disulfide bond, form A does not.,PTM:The signal sequence is not cleaved.,similarity:Belongs to the paraoxonase family.,subunit:Heterooligomer with phosphate-binding protein (HPBP). Interacts with CLU.,tissue specificity:Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Secreted, extracellular space.
組織表達(dá)： Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
科研貨號(hào)： PLA019543

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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