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LAT Polyclonal Antibody

商品貨號： PLA019293

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： LAT
蛋白名稱： Linker for activation of T-cells family member 1
Human_gene_id： 27040
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27040
Human_swiss_prot_no： O43561
Human_swiss_link： http://www.uniprot.org/uniprotkb/O43561/entry
Mouse_gene_id： 16797
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16797
Mouse_swiss_prot_no： O54957
Mouse_swiss_link： http://www.uniprot.org/uniprot/O54957
Rat_gene_id： 81511
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81511
Rat_swiss_prot_no： O70601
Rat_swiss_link： http://www.uniprot.org/uniprot/O70601
特異性： LAT Polyclonal Antibody detects endogenous levels of LAT protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38
實(shí)測條帶： 27kD
信號通路： Natural killer cell mediated cytotoxicity;T_Cell_Receptor;Fc epsilon RI;Fc gamma R-mediated phagocytosis;
功能： function:Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.,miscellaneous:Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT.,PTM:Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.,PTM:Phosphorylated on tyrosines by ZAP-70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement.,subcellular location:Present in lipid rafts.,subunit:When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A.,tissue specificity:Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.
組織表達(dá)： Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
科研貨號： PLA019293

LAT Polyclonal Antibody

Catalog No PLA019293

Product information

基因名稱： LAT
蛋白名稱： Linker for activation of T-cells family member 1
Human_gene_id： 27040
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27040
Human_swiss_prot_no： O43561
Human_swiss_link： http://www.uniprot.org/uniprotkb/O43561/entry
Mouse_gene_id： 16797
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16797
Mouse_swiss_prot_no： O54957
Mouse_swiss_link： http://www.uniprot.org/uniprot/O54957
Rat_gene_id： 81511
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81511
Rat_swiss_prot_no： O70601
Rat_swiss_link： http://www.uniprot.org/uniprot/O70601
特異性： LAT Polyclonal Antibody detects endogenous levels of LAT protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38
實(shí)測條帶： 27kD
信號通路： Natural killer cell mediated cytotoxicity;T_Cell_Receptor;Fc epsilon RI;Fc gamma R-mediated phagocytosis;
功能： function:Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.,miscellaneous:Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT.,PTM:Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.,PTM:Phosphorylated on tyrosines by ZAP-70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement.,subcellular location:Present in lipid rafts.,subunit:When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A.,tissue specificity:Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.
組織表達(dá)： Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
科研貨號： PLA019293

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

亚洲国产日韩不卡综合,明星ai换脸磁力资源种子搜索,成人性闻CCAV下载,欧美日本国产在线a小说v,亚洲欧洲综合一区二区三区,里中结衣av中文字幕