其他名稱： MCM6; DNA replication licensing factor MCM6; p105MCM
實測條帶： 90kD
信號通路： DNA replication;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能： function:May be involved in the control of a single round of DNA replication during S phase. Binds to chromatin during G1 and detach from it during S phase as if it licenses the chromatin to replicate.,polymorphism:Intronic variations in MCM6 upstream from the LCT gene are associated with adult-type hypolactasia [MIM:223100] leading to lactose intolerance, or with lactase persistance. Lactose intolerance is a normal physiological phenomenon caused by developmental down-regulation of lactase activity during childhood or early adulthood. A non-coding variation in MCM6 affects the transcriptional regulation of the LCT gene resulting in down-regulation of lactase activity. However the majority of Northern Europeans and some African populations have the ability to maintain lactase activity and digest lactose throughout life (lactase persistence).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,subunit:May interact with MCM10. Interacts with TIPIN.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Chromosome . Binds to chromatin during G1 and detach from it during S phase. .
其他名稱： MCM6; DNA replication licensing factor MCM6; p105MCM
實測條帶： 90kD
信號通路： DNA replication;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能： function:May be involved in the control of a single round of DNA replication during S phase. Binds to chromatin during G1 and detach from it during S phase as if it licenses the chromatin to replicate.,polymorphism:Intronic variations in MCM6 upstream from the LCT gene are associated with adult-type hypolactasia [MIM:223100] leading to lactose intolerance, or with lactase persistance. Lactose intolerance is a normal physiological phenomenon caused by developmental down-regulation of lactase activity during childhood or early adulthood. A non-coding variation in MCM6 affects the transcriptional regulation of the LCT gene resulting in down-regulation of lactase activity. However the majority of Northern Europeans and some African populations have the ability to maintain lactase activity and digest lactose throughout life (lactase persistence).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,subunit:May interact with MCM10. Interacts with TIPIN.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Chromosome . Binds to chromatin during G1 and detach from it during S phase. .
組織表達： Cervix,Epithelium,
科研貨號： PLA019120
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