其他名稱: A2M; CPAMD5; FWP007; Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
實測條帶: 170kD
信號通路: Complement and coagulation cascades;
功能: developmental stage:Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.,function:Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.,online information:Alpha-2 macroglobulin entry,similarity:Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.,subunit:Homotetramer; disulfide-linked.,tissue specificity:Plasma.,
其他名稱: A2M; CPAMD5; FWP007; Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
實測條帶: 170kD
信號通路: Complement and coagulation cascades;
功能: developmental stage:Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.,function:Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.,online information:Alpha-2 macroglobulin entry,similarity:Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.,subunit:Homotetramer; disulfide-linked.,tissue specificity:Plasma.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細胞定位: Secreted .
組織表達: Secreted in plasma.
tag: hot
科研貨號: PLA019048
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