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PCNA Monoclonal Antibody(12D10), AbFluor™ 555 Conjugated

商品貨號： PLA005512

適應(yīng) 性： 人,大鼠,小鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 14
基因名稱： PCNA
蛋白名稱： Proliferating cell nuclear antigen
Human_gene_id： 5111
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5111
Human_swiss_prot_no： P12004
Human_swiss_link： https://www.uniprot.org/uniprotkb/P12004/entry
特異性： PCNA Monoclonal Antibody(12D10) AbFluor? 555 Conjugated specially designed for your Immunofluorescence analysis.
組成： Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
來源： Monoclonal, Mouse IgG1
稀釋： Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:200, IF 1:200.
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
濃度： 1mg/ml
儲存： Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Store in dark.
說明書： 1
其他名稱： PCNA; Proliferating cell nuclear antigen; PCNA; Cyclin
實測條帶： 30-33kd
信號通路： DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能： disease:Antibodies are present in sera from patients with systemic lupus erythematosus.,function:This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.,online information:PCNA entry,PTM:Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases RNF8 and SHPRH, which are required for DNA repair.,similarity:Belongs to the PCNA family.,subunit:Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B/WSTF; the interaction is direct.,
相關(guān)產(chǎn)品： YT6075,YT3617,YM6211,YM6090,YM3031,YM2139,YM2138,YM2137,YM2136,YM2135,YM2134,YM2133,YM2132,YM2131,YM2130,YM2129,YM2128,KA3356C
細(xì)胞定位： Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
組織表達(dá)： Bone marrow,Fetal brain cortex,Lung,Placenta,
科研貨號： PLA005512

PCNA Monoclonal Antibody(12D10), AbFluor™ 555 Conjugated

Catalog No PLA005512

Product information

發(fā)貨日期： 14
基因名稱： PCNA
蛋白名稱： Proliferating cell nuclear antigen
Human_gene_id： 5111
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5111
Human_swiss_prot_no： P12004
Human_swiss_link： https://www.uniprot.org/uniprotkb/P12004/entry
特異性： PCNA Monoclonal Antibody(12D10) AbFluor? 555 Conjugated specially designed for your Immunofluorescence analysis.
組成： Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
來源： Monoclonal, Mouse IgG1
稀釋： Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:200, IF 1:200.
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
濃度： 1mg/ml
儲存： Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Store in dark.
說明書： 1
其他名稱： PCNA; Proliferating cell nuclear antigen; PCNA; Cyclin
實測條帶： 30-33kd
信號通路： DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能： disease:Antibodies are present in sera from patients with systemic lupus erythematosus.,function:This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.,online information:PCNA entry,PTM:Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases RNF8 and SHPRH, which are required for DNA repair.,similarity:Belongs to the PCNA family.,subunit:Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B/WSTF; the interaction is direct.,
相關(guān)產(chǎn)品： YT6075,YT3617,YM6211,YM6090,YM3031,YM2139,YM2138,YM2137,YM2136,YM2135,YM2134,YM2133,YM2132,YM2131,YM2130,YM2129,YM2128,KA3356C
細(xì)胞定位： Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
組織表達(dá)： Bone marrow,Fetal brain cortex,Lung,Placenta,
科研貨號： PLA005512

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

亚洲国产日韩不卡综合,明星ai换脸磁力资源种子搜索,成人性闻CCAV下载,欧美日本国产在线a小说v,亚洲欧洲综合一区二区三区,里中结衣av中文字幕