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SIRT1 mouse mAb

商品貨號： PLA005332

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： sirt1
Human_gene_id： 23411
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23411
Human_swiss_prot_no： Q96EB6
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q96EB6/entry
Mouse_swiss_prot_no： Q923E4
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q923E4
特異性： This antibody detects endogenous levels of SIRT1 and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： wb dilution 1:1000
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： 75SirT1;BA57G10.4;BA57G10.4;hSIR2;hSIRT1;HST2, S. cerevisiae, homolog of;NAD dependent deacetylase SIRT1;NAD dependent deacetylase sirtuin 1;NAD dependent protein deacetylase sirtuin 1;OTTHUMP00000198111;OTTHUMP00000198112;Regulatory protein SIR2 homolog 1;SIR1_HUMAN;SIR2 like 1;SIR2 like protein 1;SIR2, S.cerevisiae, homolog-like 1;SIR2-like protein 1;SIR2ALPHA;SIR2ALPHA;SIR2alpha protein;SIR2alpha protein;SIR2L1;SIRT 1;Sirt1;SIRT1 Sir2 like proteins (siruitins) type 1;SIRT1: sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);SIRT1: sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);SirtT1 75 kDa fragment;sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);Sirtuin 1; sirtuin;Sirtuin type 1;Sirtuin type 1.
實測條帶： 85-110kD
功能： catalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by nicotinamide. Activated by resveratrol (3,5,4'-trihydroxy-trans-stilbene), butein (3,4,2',4'-tetrahydroxychalcone), piceatannol (3,5,3',4'-tetrahydroxy-trans-stilbene), Isoliquiritigenin (4,2',4'-trihydroxychalcone), fisetin (3,7,3',4'-tetrahydroxyflavone) and quercetin (3,5,7,3',4'-pentahydroxyflavone). RPS19BP1/AROS acts as a positive regulator of deacetylation activity.,function:NAD-dependent deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. Involved in HES1- and HEY2-mediated transcriptional repression. Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. May serve as a sensor of the cytosolic ratio of NAD(+)/NADH, which is essential in skeletal muscle cell differentiation. Despite some ability to deacetylate histones in vitro, such activity is either weak or inexistent in vivo. In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein.,miscellaneous:Red wine, which contains resveratrol, may participate in activation of sirtuin proteins, and may therefore participate in an extended lifespan as it has been observed in yeast.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,subcellular location:Recruited to the nuclear bodies via its interaction with PML.,subunit:Interacts with TAF1B. Found in a complex with PCAF and MYOD1 (By similarity). Interacts with MLLT7/FOXO4, HES1, HEY2, p53/TP53 and PML. Interacts with RPS19BP1/AROS.,tissue specificity:Widely expressed.,
相關(guān)產(chǎn)品： YT4302,YP0488,YM1416,YM0578
細胞定位： Nucleus, PML body . Cytoplasm . Nucleus . Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491). Colocalized with APEX1 in the nucleus (PubMed:19934257). May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825). Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). .; [SirtT1 75 kDa fragment]: Cytoplasm . Mitochondrion .
組織表達： Widely expressed.
科研貨號： PLA005332

SIRT1 mouse mAb

Catalog No PLA005332

Product information

發(fā)貨日期： 7
基因名稱： sirt1
Human_gene_id： 23411
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23411
Human_swiss_prot_no： Q96EB6
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q96EB6/entry
Mouse_swiss_prot_no： Q923E4
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q923E4
特異性： This antibody detects endogenous levels of SIRT1 and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： wb dilution 1:1000
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： 75SirT1;BA57G10.4;BA57G10.4;hSIR2;hSIRT1;HST2, S. cerevisiae, homolog of;NAD dependent deacetylase SIRT1;NAD dependent deacetylase sirtuin 1;NAD dependent protein deacetylase sirtuin 1;OTTHUMP00000198111;OTTHUMP00000198112;Regulatory protein SIR2 homolog 1;SIR1_HUMAN;SIR2 like 1;SIR2 like protein 1;SIR2, S.cerevisiae, homolog-like 1;SIR2-like protein 1;SIR2ALPHA;SIR2ALPHA;SIR2alpha protein;SIR2alpha protein;SIR2L1;SIRT 1;Sirt1;SIRT1 Sir2 like proteins (siruitins) type 1;SIRT1: sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);SIRT1: sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);SirtT1 75 kDa fragment;sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);Sirtuin 1; sirtuin;Sirtuin type 1;Sirtuin type 1.
實測條帶： 85-110kD
功能： catalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by nicotinamide. Activated by resveratrol (3,5,4'-trihydroxy-trans-stilbene), butein (3,4,2',4'-tetrahydroxychalcone), piceatannol (3,5,3',4'-tetrahydroxy-trans-stilbene), Isoliquiritigenin (4,2',4'-trihydroxychalcone), fisetin (3,7,3',4'-tetrahydroxyflavone) and quercetin (3,5,7,3',4'-pentahydroxyflavone). RPS19BP1/AROS acts as a positive regulator of deacetylation activity.,function:NAD-dependent deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. Involved in HES1- and HEY2-mediated transcriptional repression. Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. May serve as a sensor of the cytosolic ratio of NAD(+)/NADH, which is essential in skeletal muscle cell differentiation. Despite some ability to deacetylate histones in vitro, such activity is either weak or inexistent in vivo. In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein.,miscellaneous:Red wine, which contains resveratrol, may participate in activation of sirtuin proteins, and may therefore participate in an extended lifespan as it has been observed in yeast.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,subcellular location:Recruited to the nuclear bodies via its interaction with PML.,subunit:Interacts with TAF1B. Found in a complex with PCAF and MYOD1 (By similarity). Interacts with MLLT7/FOXO4, HES1, HEY2, p53/TP53 and PML. Interacts with RPS19BP1/AROS.,tissue specificity:Widely expressed.,
相關(guān)產(chǎn)品： YT4302,YP0488,YM1416,YM0578
細胞定位： Nucleus, PML body . Cytoplasm . Nucleus . Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491). Colocalized with APEX1 in the nucleus (PubMed:19934257). May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825). Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). .; [SirtT1 75 kDa fragment]: Cytoplasm . Mitochondrion .
組織表達： Widely expressed.
科研貨號： PLA005332

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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