其他名稱: KLHL12; C3IP1; Kelch-like protein 12; CUL3-interacting protein 1; DKIR homolog; hDKIR
功能: domain:The BTB domain is required for interaction with CUL3.,function:Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Component of an ubiquitin-protein E3 ligase complex which includes at least CUL3 and KLHL12. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A.,tissue specificity:Highly expressed in testis and at lower levels in the submandibular salivary gland.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細胞定位: Cytoplasmic vesicle, COPII-coated vesicle .
組織表達: Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland.
其他名稱: KLHL12; C3IP1; Kelch-like protein 12; CUL3-interacting protein 1; DKIR homolog; hDKIR
功能: domain:The BTB domain is required for interaction with CUL3.,function:Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Component of an ubiquitin-protein E3 ligase complex which includes at least CUL3 and KLHL12. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A.,tissue specificity:Highly expressed in testis and at lower levels in the submandibular salivary gland.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細胞定位: Cytoplasmic vesicle, COPII-coated vesicle .
組織表達: Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland.
科研貨號: PLA004896
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