信號通路： Cytokine-cytokine receptor interaction;Cell adhesion molecules (CAMs);Toll_Like;Intestinal immune network for IgA production;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Primary immunodeficiency;Viral myocarditis;
功能： alternative products:Additional isoforms seem to exist,disease:Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) [MIM:606843]. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.,function:Receptor for TNFSF5/CD40LG.,online information:CD40 entry,online information:CD40 mutation db,similarity:Contains 4 TNFR-Cys repeats.,subunit:Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:B-cells and in primary carcinomas.,
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： [Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.
組織表達： B-cells and in primary carcinomas.
科研貨號： PLA004711
CD40 Monoclonal Antibody
Catalog NoPLA004711
Product information
發(fā)貨日期： 7
基因名稱： CD40
蛋白名稱： Tumor necrosis factor receptor superfamily member 5
信號通路： Cytokine-cytokine receptor interaction;Cell adhesion molecules (CAMs);Toll_Like;Intestinal immune network for IgA production;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Primary immunodeficiency;Viral myocarditis;
功能： alternative products:Additional isoforms seem to exist,disease:Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) [MIM:606843]. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.,function:Receptor for TNFSF5/CD40LG.,online information:CD40 entry,online information:CD40 mutation db,similarity:Contains 4 TNFR-Cys repeats.,subunit:Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:B-cells and in primary carcinomas.,
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： [Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.
組織表達： B-cells and in primary carcinomas.
科研貨號： PLA004711
Hunan UPT Biotechnology Co.,Ltd
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