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Ataxin-1 Monoclonal Antibody

商品貨號(hào)： PLA004652

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

在線咨詢

MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： ATXN1
蛋白名稱： Ataxin-1
Human_gene_id： 6310
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6310
Human_swiss_prot_no： P54253
Human_swiss_link： http://www.uniprot.org/uniprotkb/P54253/entry
Mouse_swiss_prot_no： P54254
Mouse_swiss_link： http://www.uniprot.org/uniprot/P54254
特異性： Ataxin-1 Monoclonal Antibody detects endogenous levels of Ataxin-1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： ATXN1; ATX1; SCA1; Ataxin-1; Spinocerebellar ataxia type 1 protein
功能： alternative products:At least 2 isoforms are produced,disease:Defects in ATXN1 are the cause of spinocerebellar ataxia type 1 (SCA1) [MIM:164400]; also known as olivopontocerebellar atrophy I (OPCA I or OPCA1). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.,domain:The AXH domain is required for interaction with CIC.,function:Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.,miscellaneous:The self-association seems to be necessary to form nuclear aggregates.,online information:Ataxin-1 entry,polymorphism:The poly-Gln region of ATXN1 is highly polymorphic (4 to 39 repeats) in the normal population and is expanded to about 40-83 repeats in spinocerebellar ataxia 1 (SCA1) patients.,similarity:Belongs to the ATXN1 family.,similarity:Contains 1 AXH domain.,subcellular location:Colocalizes with USP7 in the nucleus.,subunit:Interacts with CIC (By similarity). Interacts with ANP32A, PQBP1, UBIN, ATXN1L, USP7 and ZNF804A.,tissue specificity:Widely expressed throughout the body.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus . Colocalizes with USP7 in the nucleus. .
組織表達(dá)： Widely expressed throughout the body.
科研貨號(hào)： PLA004652

Ataxin-1 Monoclonal Antibody

Catalog No PLA004652

Product information

發(fā)貨日期： 7
基因名稱： ATXN1
蛋白名稱： Ataxin-1
Human_gene_id： 6310
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6310
Human_swiss_prot_no： P54253
Human_swiss_link： http://www.uniprot.org/uniprotkb/P54253/entry
Mouse_swiss_prot_no： P54254
Mouse_swiss_link： http://www.uniprot.org/uniprot/P54254
特異性： Ataxin-1 Monoclonal Antibody detects endogenous levels of Ataxin-1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： ATXN1; ATX1; SCA1; Ataxin-1; Spinocerebellar ataxia type 1 protein
功能： alternative products:At least 2 isoforms are produced,disease:Defects in ATXN1 are the cause of spinocerebellar ataxia type 1 (SCA1) [MIM:164400]; also known as olivopontocerebellar atrophy I (OPCA I or OPCA1). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.,domain:The AXH domain is required for interaction with CIC.,function:Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.,miscellaneous:The self-association seems to be necessary to form nuclear aggregates.,online information:Ataxin-1 entry,polymorphism:The poly-Gln region of ATXN1 is highly polymorphic (4 to 39 repeats) in the normal population and is expanded to about 40-83 repeats in spinocerebellar ataxia 1 (SCA1) patients.,similarity:Belongs to the ATXN1 family.,similarity:Contains 1 AXH domain.,subcellular location:Colocalizes with USP7 in the nucleus.,subunit:Interacts with CIC (By similarity). Interacts with ANP32A, PQBP1, UBIN, ATXN1L, USP7 and ZNF804A.,tissue specificity:Widely expressed throughout the body.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus . Colocalizes with USP7 in the nucleus. .
組織表達(dá)： Widely expressed throughout the body.
科研貨號(hào)： PLA004652

Hunan UPT Biotechnology Co.,Ltd

Website：m.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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