特異性: This antibody detects endogenous levels of Human, Mouse FA11 (heavy chain, Cleaved-Arg387, protein was cleaved amino acid sequence between 387-388 )
組成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源: Polyclonal, Rabbit,IgG
稀釋: WB 1:1000-2000 ELISA 1:5000-20000
純化工藝: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度: 1 mg/ml
儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
其他名稱: Coagulation factor XI (FXI;EC 3.4.21.27;Plasma thromboplastin antecedent;PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
實測條帶: 40 66kD
功能: catalytic activity:Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.,disease:Defects in F11 are the cause of F11 deficiency [MIM:612416]; also called plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a blood coagulation abnormality occurring in high frequency in Ashkenazi jews. F11-deficient patients are prone to excessive bleeding after haemostatic challenge.,function:Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.,online information:Factor XI entry,PTM:Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.,similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 apple domains.,subunit:Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond.,tissue specificity:Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3052
細(xì)胞定位: Secreted.
組織表達(dá): Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
特異性: This antibody detects endogenous levels of Human, Mouse FA11 (heavy chain, Cleaved-Arg387, protein was cleaved amino acid sequence between 387-388 )
組成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源: Polyclonal, Rabbit,IgG
稀釋: WB 1:1000-2000 ELISA 1:5000-20000
純化工藝: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度: 1 mg/ml
儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
其他名稱: Coagulation factor XI (FXI;EC 3.4.21.27;Plasma thromboplastin antecedent;PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
實測條帶: 40 66kD
功能: catalytic activity:Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.,disease:Defects in F11 are the cause of F11 deficiency [MIM:612416]; also called plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a blood coagulation abnormality occurring in high frequency in Ashkenazi jews. F11-deficient patients are prone to excessive bleeding after haemostatic challenge.,function:Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.,online information:Factor XI entry,PTM:Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.,similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 apple domains.,subunit:Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond.,tissue specificity:Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3052
細(xì)胞定位: Secreted.
組織表達(dá): Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
科研貨號: PLA004405
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