特異性: Cleaved-CD97α (L530) Polyclonal Antibody detects endogenous levels of fragment of activated CD97α protein resulting from cleavage adjacent to L530.
組成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源: Polyclonal, Rabbit,IgG
稀釋: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
純化工藝: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度: 1 mg/ml
儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
其他名稱: CD97; CD97 antigen; Leukocyte antigen CD97; CD antigen CD97
實測條帶: 55kD
功能: domain:Binding to chondroitin sulfate is mediated by the fourth EGF domain.,domain:The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.,function:Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.,induction:Rapid up-regulation during lymphocyte activation.,PTM:Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 5 EGF-like domains.,subunit:Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate.,tissue specificity:Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompagnied by detectable levels of soluble CD97 in the synovial fluid.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細胞定位: Cell membrane ; Multi-pass membrane protein .; [Adhesion G protein-coupled receptor E5 subunit alpha]: Secreted, extracellular space .
組織表達: Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.
特異性: Cleaved-CD97α (L530) Polyclonal Antibody detects endogenous levels of fragment of activated CD97α protein resulting from cleavage adjacent to L530.
組成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源: Polyclonal, Rabbit,IgG
稀釋: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
純化工藝: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度: 1 mg/ml
儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
其他名稱: CD97; CD97 antigen; Leukocyte antigen CD97; CD antigen CD97
實測條帶: 55kD
功能: domain:Binding to chondroitin sulfate is mediated by the fourth EGF domain.,domain:The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.,function:Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.,induction:Rapid up-regulation during lymphocyte activation.,PTM:Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 5 EGF-like domains.,subunit:Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate.,tissue specificity:Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompagnied by detectable levels of soluble CD97 in the synovial fluid.,
相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
細胞定位: Cell membrane ; Multi-pass membrane protein .; [Adhesion G protein-coupled receptor E5 subunit alpha]: Secreted, extracellular space .
組織表達: Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.
科研貨號: PLA004322
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